Sentence examples for enhancing activation of from inspiring English sources

In vitro studies have shown that the V600E mutation, which is located in the protein's activation loop, causes a 500-fold increase in the enzymatic activity of BRAF, enhancing activation of its downstream target, ERK [ 11].

We have advanced a novel technology for enhancing activation of antigen-specific CD4+ T helper cells whereby a fragment of the MHC class II-associated invariant chain (Ii-Key) is linked to an MHC class II epitope.

β-arrestin works as a scaffold protein to recruit Raf, MEK and ERK to the receptor, enhancing activation of ERK [10].

In addition to enhancing activation of the well-known pro-survival factors, ERK, Akt and CREB, our study demonstrated that EDC exerted a prolonged attenuation of phosphorylation of JNK at Thr183/Tyr185, phosphorylation sites known to be critical for JNK activation [61].

In this case, these mutations are of gain-of-function type, which presumably function by inappropriately enhancing activation of certain transcription programmes leading to increased proliferation.

α1-Containing GABAA receptors are likely involved in the motor incoordination since benzodiazepines induce ataxia by enhancing activation of α1-containing GABAA receptors (27).

In addition, increase of intracellular PP2A activity enhances activation of HIV-1 promoter by phorbol myristate acetate (PMA), whereas inhibition of PP2A prevents its activation [103].

Thus, heterodimerization of caspase-1 with caspase-4 or -5 may represent a means to activate or enhance activation of caspase-1.

In addition, recent reports demonstrated significantly enhanced activation of the Rac/p21-activated kinase pathway in VASP −/− cells [13].

Metformin activates AMPK by inhibiting mitochondrial respiration and increasing 5′-AMP, which enhances activation of AMPK by LKB1 (1).

However, in our situation, enhanced activation of peptide carboxyl groups will be useful for allowing the peptides to link together.