Group-housing of male C57BL/6N mice is known to result in aggressive behaviour between cage mates that, importantly, enhances a variability in anxiety-related and a number of other behaviours, as well as having a significant impact on the stress response.
Furthermore, the mutation by Tyr of two proline residues in APP-RP1, which are essential for the binding of some linear peptides to Abl-SH3, demonstrates the effectiveness of the scaffold in enhancing the variability in the design of high-affinity and high-specificity ligands for any SH3 domain.
Here, we suggest that animals exploit the controlled shuffling of transposons to enhance genomic variability in conjunction with a molecular screening mechanism to exclude deleterious events.
Although this may enhance immune system variability in response to challenges by pathogens, a consequence of the complex domestication history of the chicken is that introgression, multiple origins and migration are likely to have altered the pattern of diversity at this locus, complicating selection signatures.
This threshold element further enhances cell-to-cell variability in ppERK levels, and results in bimodal responses at the population level.
The alignment was created in order to enhance sequence variability and in this way, only the key conserved residues for structure, folding, and function could be identified.
This modification is considered to enhance understanding of the variability in the direction of natural selection: selection does not always favor the long flight, which will lead to the rejection of teleological thoughts.
Gene copy number variation (CNV) is well documented as an important mechanism to enhance gene expression and variability in T. cruzi.
We demonstrated that at early times (4 – 6 hours post-infection) autocrine signaling is dominant and enhances the cell-to-cell variability in IFN-β due to stochastic induction.
Consequently the development of clinical pathways has the potential to reduce the current variability in care, enhance guideline adherence, and improve outcomes for patients.
