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Over-expression of Hsp70 in BHK-21 cells engineered to produce recombinant factor VIII promotes resistance to apoptosis and enhances secretion.
Different effects attributed to TGF-β can play a causal role in this context: one, the induction of the CTGF by TGF-β as shown in airway smooth muscle cells facilitates the binding of VEGF to the ECM [78]; second, the bone morphogenic protein (BMP), part of the TGF-β superfamily, enhances secretion of the VEGF protein in murine proteoblastic KS483 cells [79].
Osteopontin enhances secretion, cell motility, and extracellular matrix invasion and is a general cytokine.
Malfunction of the AP-3 complex attenuates the degradation process, which in turn enhances secretion.
Indeed, Riedl et al. [ 31] have shown that hyperglycaemia enhances secretion of carnosinase and its activity.
The rhamnogalacturonan I-arabinan fraction of pectin from a medicinal herb enhances secretion of granulocyte colony-stimulating factor (G-CSF) by murine colonic MCE 301 cells [ 17].
Similar(51)
However, limitations exist as some proteins cannot be secreted efficiently, leading to strategies to enhance secretion efficiency by modifying the secretion signal leader.
As a consequence, high glucose stress increased extracellular yellow pigments production by enhancing secretion and trans-membrane conversion of intracellular pigments to the broth.
In addition, microparticle stimulation of DCs also enhanced secretion of the cytokines IL-12p40 and IL-6, a phenomenon found to be dependent on polymer chemistry.
On the other hand, introduction of the polar amino acid asparagine into the C-terminal region enhanced secretion of the recombinant proteins.
In this study we describe the finding of novel site(s) of HlyB responsible for enhancing secretion of CGTase in E. coli.
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