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It will be informative to see whether combinatorial treatment with these reagents enhances potency of their anti-cancer activity by synergistically increasing PML protein accumulation.
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Additionally, the C-terminal repeats bind Ca2+ thereby enhancing potency of TcdA [8].
Solution to the problem is in enhancing potency of new drugs to shorten course of treatment, ensure patient's compliance, and achieve parasitological cure.
In addition, we discovered key differential sensitivities to targeted agents between two-dimensional and three-dimensional cultures, and also demonstrated enhanced potency of some agents against cell migration/invasion compared with proliferation, suggesting their preferential utility in metastatic disease.
One way to enhance potencies of DNA vaccines is to increase antigen expression in professional antigen presenting cells, such as dendritic cells.
Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors.
In vitro studies with CTA091 show that it enhances the potency of 1α,25(OH)2D3.
EL102 enhances the potency of docetaxel in a xenograft model of the CWR22 prostate cancer.
Thus, presentation of HA1-2 in the context of a flagellin fusion protein significantly enhances the potency of HA1-2 an an immunogen.
Taken together these findings demonstrate that the delivery of the immunostimulatory peptide Hp91 inside PLGA-NPs enhances the potency of the peptide and efficacy of a breast cancer vaccine.
Compounds with a benzothiazole group (4 – 6 ; 46–330 nM range) or an indolyl-sulfonamide linked to the quinol (13 – 25, 12 170 nM range) were generally potent, confirming the previous observation that the indolyl enhances the potency of these compounds.
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