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Incubation of SVZ cells with rhEPO significantly increased the number of O4 positive cells in a dose dependent manner with a maximum increase at 10 units/ml (Fig. 5), suggesting that EPO enhances generation of oligodendrocyte progenitor cells.
Quantitative data analysis shows that rhEPO treatment substantially increased the percentage of CNPase cells reactive to BrdU (12.5±2.1%, n = 5) compared with the rats treated with saline (5.3±1.6%, n = 7) 28 days after stroke, suggesting that EPO enhances generation of new myelinating oligodendrocytes.
In addition, it causes dysfunction and apoptosis of endothelial cells, and enhances generation of free radicals (including superoxide anion), which in turn quenches NO.
Alternative translation initiation and thus C/EBPβ isoform production is regulated through the mammalian target of rapamycin (mTOR) pathway: activation of mTOR enhances generation of LIP and inhibition of mTOR enhances LAP production (Calkhoven et al, 2000; Jundt et al, 2005).
This study shows that deficiency of Lp-PLA2 on hematopoietic cells attenuates systemic inflammation after MI, impairs leukocyte infiltration into infarcts, and enhances generation of reparative Ly-6Clow macrophages, leading to less adverse LV remodeling and improved recovery of LV function.
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Additionally, entrepreneurs possess generic competences that enhance generation of diversity and diffusion of new knowledge (Drucker 2014; see for university-run enterprises, Zhou 2014).
The redox cycle among the active metals (M2+ ↔ M3+ ↔ M2+) and Cu enhanced generation of Co II)–OH complex are critical for the remarkable performance in CuCo@MnO2/PMS system.
In agreement with the results obtained from analyzing the CTF levels, the E682K mutation blocked the generation of the Aβ11 40/42 peptide while it enhanced generation of Aβ1 40/42 peptide (Fig 3D).
SDMA plays a role in leukocyte activation by enhancing generation of ROS, which is attributed to increased calcium influx via store-operated Ca2+ channels [ 52] and activation of nuclear factor (NF) κB resulting in cytokine production [ 44].
Since expression of the entire mitochondrial genome is necessary for the maintenance of mitochondrial functions, including electron transport, small changes in the mtDNA sequence can result in profound impairment of such functions, thereby enhancing generation of free radicals, which in turn accelerates the rate of DNA mutation.
Expression of antigen in the liver generally enhances the generation of induced FoxP3+ Treg cells and has proven effective in models of uveitis and MS [ 33,34 ].
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