In parallel, depending on the nature and intensity of stresses, the polypeptide chain itself, both free and on the surface of VLPs, may denature to a various extent enhancing fluctuations of the total antigen level.
Interestingly the dimerization arm, a β hairpin in domain II that protrudes from the rest of Her2, together with the spatially adjacent regions, undergoes enhanced fluctuations when trastuzumab binds.
To trigger fusion, it may not be necessary to dissociate the H3 motif completely, it may only be necessary to enhance fluctuations at the N-terminus or bring the other SNARE partners into close proximity to the more dynamic syntaxin N-terminus.
Keeping close pace with the variation of the SAM, the variation in the zonal (eastward) geostrophic flow of the ACC derived from the OBP EOF solution is found to exhibit an obviously enhanced fluctuation in the southern ACC on the order of a few mm/s during the past decade.
The presence of interfacial waves enhances turbulence fluctuations in inclined oil water flows.
Overall, the data suggest that the specific hydration state enhances macromolecular fluctuations but, at the same time, increases thermal stability.
In the case of LM-G41R, detailed characterization of proteolysis products in combination with molecular dynamic simulations supports that G41R mutation enhances conformational fluctuations in the N-terminal region of AGT, thus accelerating cleavage by proteases [ 43, 68].
As discussed later (Fig. 4), the temperature shows enhanced longitudinal fluctuations near the equator.
At lower shear rate, flow enhances concentration fluctuation and induces phase segregation.
The results show that fluidization is enhanced and fluctuations of the local two-phase flow structure become more intense with increasing bed temperature.
