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Formin homology 2 domain containing protein (FHOD1), a mammalian formin, regulates cytoskeletal architecture, enhances cell migration, and induces gene expression from the serum response element.
Using an in vitro model for wound healing, we observed that shikonin enhances cell migration of intestinal epithelial cells through a mechanism that involves TGF-β1 induction.
Additionally, MMP7 shedding of syndecan-1 enhances cell migration and wound closure.
FHOD1, another formin family member, acts through Rac and enhances cell migration when overexpressed [38].
Capicúa knockdown also enhances cell migration.
PI3K/Akt/NF-κB enhances cell migration and invasion [ 25].
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Here, we report that re-expression of SMAD4 in SMAD4-null PDAC cells does not affect tumor cell growth in vitro or in vivo, but significantly enhances cells migration in vitro.
In addition, in some cancer cells, TNF- α enhances cells migration and metastasis through NF- κB-dependent induction of the chemokine receptor CXCR4, monocyte chemoattractant protein-1 (MCP-1), IL-8 and intercellular adhesion molecule-1 (Kulbe et al, 2005).
Therefore, the micro/nanofibers can simulate the extracellular matrix and enhance cell migration and proliferation.
Increasing doses of lithium (upto 15 mM) increased basal Wnt signaling and enhanced cell migration into the simulated wound site.
This abnormal expression of FLJ10540 in mammalian cells is able to enhance cell migration and invasion.
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