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Overexpressed VDAC1 in HeLa cells enhances cell death upon treatment with H2O2, staurosporine (STS), TG or As2O3 (Keinan et al., 2013).
In summary, this study shows that structural modification of the known ceramidase inhibitors B-13 and LCL-464 generates more potent ceramidase inhibitors that are active in intact cells and not only elevates the cellular ceramide levels, but also enhances cell death.
Furthermore, in colon cancer, CQ enhances cell death induced by topotecan, a DNA damage inducer.
The mechanism by which H2S enhances cell death under ischemic conditions requires thorough investigations.
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A [ 30].
This hypothesis was confirmed by the fact that fructose enhances cell death and can be blocked by Z-VAD fmk.
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"To the best of my knowledge, caffeine and caffeine sodium benzoate are the first examples of substances that have both a sunscreen effect and enhance cell death in a DNA-damaged tissue".
The p38 kinase inhibitor, SB203580 were partially protected 3AO cells against growth inhibition by E2, while inhibitor of JNK, SP600125 enhanced cell death induced by E2.
Long AANTs triggered enhanced cell death, morphological changes, tumor necrosis factor α (TNF-α) release, LMP and ER stress than short AANTs.
Numerous studies, performed with various eukaryotic cells, have demonstrated the efficacy of high-Z NPs to enhance cell death in mammalian cells (Usami et al. 2008; Charest et al. 2010).
The deficiency of Atg5 gene leads to the reduction of thymic cellularity and decreased number of peripheral T lymphocytes through enhancing cell death, suggesting the role of autophagic proteins in the regulation of T cell homeostasis [35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com