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These results demonstrate that treatment with a soluble form of ActRIIA (ACE-011) enhances bone mass and bone strength in cynomolgus monkeys, and provide strong rationale for exploring the use of ACE-011 to prevent and/or treat skeletal fragility.
Deletion of a single allele of Dkk-1 enhances bone mass in mice [ 22].
PPAR γ repressed Runx2-mediated OC transcription, and its insufficiency enhances bone mass through osteoblast formation of bone marrow progenitors.
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In genetically modified mice, enhanced bone mass and enhanced stiffness, strength and mineral concentration of the cortical bone matrix are generally associated with reduced TGF-β signaling [ 3, 20, 23].
Another study which investigated the effects of AT2 receptor blocker on bone mass revealed that AT2 receptor as well as renin and ACE were expressed in bone and that AT2 receptor blocker treatment enhanced bone mass through both enhancement of osteoblastic activity and suppression of osteoclastic activity in vivo [ 23].
Participating in sports during early puberty may enhance bone mass.
Thus the mechanisms by which PGE2 and FA lead to enhanced bone mass are distinct.
These data suggest physical activity could enhance bone mass concurrently with sclerostin-neutralizing antibodies, but treatment strategies should consider the influence of age on ultimate load-induced bone mass gains.
In the field of osteoporosis, there has been growing interest in anabolic agents that enhance bone mass and improve bone architecture.
Studies have attempted to enhance bone mass in children using dairy foods [ 35- 37] or calcium supplements [ 38- 41].
Our results showed that silencing of miR-542-3p miR-542-3p miR-542-3p bone mass in sham mice and enhanced bone mass gain in Ovx mice.
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