Sentence examples for enhancer transcripts from inspiring English sources

Examples are likely to include: (i) novel unannotated protein-coding and non-coding genes, (ii) enhancer transcripts, or (iii) post poly (A) transcription for some well-annotated Pol II genes with low expression levels.

These paired TUs can indicate annotated TSSs, unannotated TSSs, or other regulatory transcription activities such as lncRNA or enhancer transcripts.

(4) Enhancer transcripts (eRNAs).

Conversely, intergenic and enhancer transcripts are enriched for upregulation (p < 4 × 10-25; Fisher's exact test) at every time point of TNFα treatment, which is consistent with their putative gene activation function.

Moreover, GRO-seq also reveals the expression of a divergent transcript generated from the NFKB1 promoter, as well as bi-directional enhancer transcripts (eRNAs) originating ~50 kb upstream of the NFKB1 promoter, which may mark functional enhancers for NFKB1.

Examples in this category may include: (1) genes with promoter proximal RNA Pol II pausing, but very low levels of transcription in the gene body, (2) divergent transcripts from internal start sites (antisense), (3) intronic enhancer transcripts, or (4) short cryptic transcripts of unknown function.

A divergent transcript was only included if (1) >10% of the transcript overlapped the proximal region of a promoter (± 500 bp relative to the TSS) driving expression of a primary transcript >1 kb in size on the opposite strand and (2) the transcript was <50% the size of the primary transcript, which effectively excluded divergent enhancer-transcript pairs.

Collectively, these findings suggest an essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts.

As a complementary analysis, we identified human enhancers for the three genes using the database provided in [ 34] that predicts active enhancers based on the expression of balanced bi-directional low expressed enhancer RNA transcripts.

The enhancer associated transcripts identified by Kim et al. 2010 [ 38] are generally short, <2 kb in length, and lincRNAs were defined as at least 5 kb in length.

We propose that characterizing and manipulating these enhancer-associated transcripts could provide a novel approach to awaken the dormant regenerative potential of the adult mammalian heart.