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However, when splicing of the Arabidopsis TRP1 (formerly called PAT1) first intron was prevented, it was still able to enhance expression to about 50% of the enhancement mediated by the intact intron [ 9, 14].
The sensitivity enhancement mediated by the presence of nanowires has also been clarified qualitatively based on the dispersion relation between metal film involving nanowires and surrounding dielectric medium.
The enhancement mediated by repeat 11 appeared somewhat tolerant of sequence requirements.
The enhancement mediated by MPL was completely negated by prior treatment with DT in lang-DTREGFP recipients, regardless of whether syngeneic or allogeneic BM-DCs were injected (Fig. 4B), indicating that MPL enhance CD8+ T cell priming by maturing the langerin+ CD8α+ DCs.
It is possible that these elements contribute not only to the substantial enhancement mediated by spliced introns, but also to the low-level enhancement mediated by unspliced introns.
The enhancement mediated by synJ was found to be at the post-transcriptional level.
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Last, but not least, it will be necessary to explicitly study the case of radio-enhancement mediated by NPs in the cytoplasm.
These rate enhancements, mediated by cavitation, are believed to originate from the build up of high local pressures (up to 1000 atm) and temperatures (up to 5000 K), as well as increased catalytic surface areas.
This concept led to the identification of biological mechanisms involving antibody mediated enhancement (ADE), mediated by non-neutralizing antibodies [5], [6], as well as exacerbated activation of cross-reactive T cell clones [7], [8], [9], [10], both acquired after primary infection.
Thus, tethered compounds that link Asc or other enhancers to specific aminergic drugs so that enhancement is mediated only at specific receptor subtypes will be a preferred direction for the development of future drugs [35].
Enhancement is mediated by clusters of epitopes on the S protein (33, 34).
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