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To characterize the kinetic features, maximum enhancement (ME), time to peak (TP), uptake rate (UR), washout rate (WR), and area under the curve are extracted from the time-intensity curve of each voxel.
(a) Coronal hole area in EUV, (b) coronal hole area that shows microwave enhancement (ME), (c) EUV intensity averaged over the coronal hole area, (d) and the microwave brightness temperature (Tb) averaged over the ME area (from Akiyama et al. 2013).
From these data, the mean enhancement (mE) for the whole tumour volume of interest was calculated.
AMPH = amphetamines; CE = cognitive enhancement; ME = mood enhancement; MPH = Methylphenidate; OTC = over the counter.
Maximum enhancement (ME), rate of early enhancement, and maximum rate of enhancement were assessed in the MCP.
For measurements of enhancement, the mean enhancement (mE) present across the entire volume of the lesion was calculated.
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"These mood enhancements put me in the state of artificial peace and I felt like I was made from cardboard".
7 DCE MRI was undertaken pre and post-abatacept therapy, with measurement of rates of contrast enhancement (IRE and ME, shown to correlate with inflammatory activity and blood vessel density) 15 confirming a general reduction in the IRE and ME values of all regions evaluated, with a significant reduction in ME-global.
Finally, Etype was categorized as type 1 if the SI increased with no subsequent decrease or levelling (threshold as late enhancement > 10%% of ME); and type 3 if SI increased rapidly and then decreased after a peak (threshold as late enhancement < 10%% of ME); and type 2 when the SI levelled following maximum enhancement (threshold as late enhancement within ±10%% of ME).
Fragments were run both on a non-denaturing 6% polyacrylamide gel at 6 W (3000 V, 300 mA) for 16-18 hours and on a MDE™ gel (Mutation Detection Enhancement, BMA products, Rockland, ME) for 8 hours at room temperature.
MCP, metacarpophalangeal; ME, maximum synovial enhancement; MRI, magnetic resonance imaging; MV maximum enhancement velocity; REE, rate of early enhancement.
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