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The fact that choline synthesis is really enhanced upon salt treatment is supported from the enhancement in the expression of the gene encoding SAM synthesizing enzyme, S-adenosylmethionine synthase, SAMS (Table 3, Fig. 2), which uses methionine and ATP as substrates.
A similar enhancement in the expression of p110δ protein and mRNA upon TNFα stimulation was also detected in human synovial fibroblasts isolated from patients with rheumatoid arthritis.
In our study, real time RT-PCR analysis demonstrates a significant enhancement in the expression of PPARγ in colorectal tumours as compared to normal surrounding mucosa.
Significant enhancement in the expression of surface markers, including CD54, I-Ab, and CD 86, was observed after incubating BMDCs with the adjuvants overnight.
Western blotting analyses demonstrated significant enhancement in the expression of PPAR γ in grade 3 ovarian tumours compared to benign ovarian tumours and normal ovaries.
In fact, a significant enhancement in the expression of proteins associated with mitochondrial electron transport chain and ATP synthesis was noticed with increasing levels of ROS in seminal plasma.
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Recently, several studies have highlighted a complementary role of neutrophils in enhancement of the expression of receptors and antimicrobial defenses on epithelial cells in mucosal candidiasis (Schaller et al., 2004; Steubesand et al., 2009; Weindl et al., 2007; Weindl et al., 2011).
Furthermore, as mentioned above, glucocorticoids can have actions other than as anti-inflammatory agents, for example, in synergistic enhancement of the expression of TLR2 by H. influenzae (Shuto et al, 2002).
Overall, the transcriptomic analysis reveals a marked enhancement of the expression of genes involved in iron scavenging in the hemA mutant when treated with CORM-3.
According to the enhancement of the expression of st3gal4 in the presence of B. thetaiotaomicron, we can assume that there is a mechanism by which this bacterium modulates the composition of mucus chain O-glycans by impacting directly enzyme expression of the host.
The enhancement of the expression of these chemokines in tumour/tumour microenvironment could identify novel strategies for the improvement of current immunotherapies (Muthuswamy et al, 2012; Pescatori et al, 2013).
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