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During the transdermal industry's age of leeching and cupping in the 1970s, a compound called dimethylsulfoxide (DMSO) was the enhancement agent of choice.
Schizophyllan is a biopolymer used as a skin care product and immunity enhancement agent.
l-Glutaminase (l-glutamine amidohydrolase, EC 3.5.1.2) is a deamiding enzyme that has current focus on a therapeutic potentials and flavor enhancement agent in food industry.
In biomedicine, many studies demonstrate SPIO NP applications in diagnosis and treatment, such as a contrast enhancement agent for magnetic resonance imaging, drug carriers for a drug delivery system, generator of heat for tumor hyperthermia and detoxification of biological fluids [6 8].
Focus in the past three decades has been on topical formulations with a 15% paromomycin ointment (with the penetrating enhancement agent, 12% methylbenzethonium chloride), proving effective in clinical studies and currently available from TEVA (Israel).
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These hybrid NPs can be ideally used as magnetic resonance imaging (MRI) contrast enhancement agents.
Presumptive test agents for biological materials (blood, semen and saliva) and those used as fingerprint enhancement agents were both used.
Increasing attention has been focused on the use of nanostructures as contrast enhancement agents in medical imaging, especially in computed tomography (CT).
In the biotechnology area, magnetic nanoparticles for drug screening, contrast enhancement agents, magnetic resonance imaging, medicine and bio-separation are focused.
Furthermore, the decontamination efficiencies are equivalent to previous electrokinetic studies that utilised hazardous chemical enhancement agents demonstrating the potential of the technique for use on nuclear licensed site.
In MRI, magnetic nanoparticles serve as contrast enhancement agents, in drug delivery, they function as drug carriers delivering and releasing the drug into target cells, while in hyperthermia, they serve as generator of heat under alternating current magnetic field.
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