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These data demonstrate that continuous exposure to S. venezuelae metabolites causes progressive degeneration across different C. elegans neuronal subtypes and that DA neurons exhibit both an accelerated and enhanced vulnerability to the degenerative effect.
Moreover, developmental PQ + MB exposures enhanced vulnerability to this pesticide regimen when administered subsequently in adulthood.
Second, cybrid cells (cytoplasmic hybrid cells: mitochondrial DNA-depleted recipients of mitochondria from other sources) containing mitochondria from AD patients have shown enhanced vulnerability to Aβ [ 121].
These z-scores were summed (characteristics that enhanced vulnerability were added and those that were protective were subtracted) and a composite index value was assigned to each census tract.
Our findings indicate that mitochondria in tau transgenic pR5 mice display enhanced vulnerability towards Aβ insult in vitro [ 57, 65], suggesting a synergistic action of tau and Aβ pathologies on this organelle.
These effects suggest enhanced vulnerability of the prefrontal cortex to Pb neurotoxicity during childhood, a hypothesis that has been supported by imaging studies revealing specific structural (Cecil et al. 2008) and metabolic (Cecil et al. 2011; Meng et al. 2005) Pb-associated alterations in this region of the brain.
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Griffin, E. A. et al. Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5.
Therefore, our study shows that forest loss could enhance vulnerability to extirpation through constraints placed on reproduction.
But making mistakes is part of parenting; we can learn from them and they can enhance vulnerability, authenticity, and connection with our children.
Taking into consideration that issues related to immigration can enhance vulnerability to SAD, we developed a cognitive-behavioral therapy that addressed the cultural elements involved in the emergence of SAD with this patient.
Whereas a brief period of controllable stress, experienced with general arousal and excitement, can be a challenge and might thus be beneficial, chronically elevated levels of circulating corticosteroids are believed to enhance vulnerability to a variety of diseases, including affective disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com