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Importantly, others show that cancer cells with IDH mutations become insensitive to treatment with mutant IDH inhibitors in vivo, owing to the metabolic rewiring and enhanced usage of the TCA cycle (Grassian et al., 2014; Tateishi et al., 2015).
Sterol depletion in cultured cells increased flux through the Bloch pathway, whereas overexpression of 24-dehydrocholesterol reductase (DHCR24) enhanced usage of the MK R pathway.
A key indicator of translational selection within genomes is the enhanced usage of a specific set of codons (i.e., optimal codons) in highly expressed genes as compared with lowly expressed genes.
With enhanced usage of A2 the chance of receiving functional GUS at a single integration site is increased by one third compared to exclusive usage of A1 emphasizing the potential of GT DsB for gene trapping.
Among the conspicuous characteristics featuring its hyperthermophilic adaptation are overrepresentation of purine bases in protein coding sequences, higher GC-content in tRNA/rRNA sequences, distinct synonymous codon usage, enhanced usage of aromatic and positively charged residues, and decreased frequencies of polar uncharged residues, as compared to those in mesophilic organisms.
Moreover, from examination of Table 2, it is evident that for six of seven comparisons where the differences in RSCU between tissues were greater than 0.1, the microspore had enhanced usage of G or C ending codons (which were notably also the preferred codons in Z. mays and T. aestivum), a trend consistent with greater selective pressure.
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· The enhanced use of gangsters to further the plot.
Isobutanol production could be even more enhanced after adapting the codon usage of the truncated valine biosynthesis genes to the codon usage of highly expressed glycolytic genes.
These results are helpful for investigating the mechanisms of HPAM-sulfide interaction and optimizing the usage of HPAM for enhanced oil recovery in oil reservoirs with sulfide ions produced by sulfate reducing bacteria.
Findings of flexibility in the representation and usage of language and enhanced executive control indicate that early bilingualism should be accompanied by advanced skills in identifying effective responses in conversation.
Besides being a potential solution for content adaptation, scalable video schemes may also allow an efficient usage of radio resources in enhanced MBMS. Figure 1 Scalable video transmission.
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