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Because sufficient concentration of intracellular tRNA and optimized codons of recombinant proteins enhanced translation efficiency, we hypothesized that sufficient supplement of host's tRNA improved protein productivity in mammalian cells.
Many of these N-10 functionalized compounds have enhanced translation inhibition activities against E. coli ribosome relative to azithromycin while a subset inhibited the growth of representative susceptible bacteria strains to about the same extent as azithromycin.
For example, enhanced translation and verification methodologies are needed to ensure the comparability of assessment instruments across the range of languages and cultures participating in international surveys.
Following radiotherapy, tumor reoxygenation leads to: (1) nuclear accumulation of HIF-1 in response to reactive oxygen, and (2) enhanced translation of HIF-1-regulated transcripts secondary to stress granule depolymerization.
This might lead to a more efficient ribosomal recycling and enhanced translation initiation at the 5'end of the mRNA.
Figure 2C also shows that use of the ARCA cap enhanced translation by between 1.5 and 1.8 fold.
In subsequent experiments, we determined whether enhanced translation mediated by the utrophin A 5'UTR in response to PDN treatment results from induced IRES activity.
The 5′-UTR intron enhanced translation efficiency for both Gladiolus and Arabidopsis.
This suggested enhanced translation efficiency at low temperatures, which was confirmed when we observed increased resistance to translation inhibitor paromomycin.
The cap enhanced translation of Luc mRNAs with TMV and crTMV 5′ UTRs by more than 10-fold.
33 This implies an intracellular increase of Leu that could have enhanced translation mainly through augmentation of mTOR pathway signaling (Fig. 1 and Figs. 6, 7, and 8).
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