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Enhanced TRAIL sensitivity is due to TRAIL receptor up-regulation induced by gp120.
It has been shown that decreased TRAIL receptor level or increased decoy TRAIL receptor level can lead to enhanced TRAIL resistance [12].
These findings suggest that HIV infection renders hepatocytes more susceptible to liver injury during disease states associated with enhanced TRAIL production such as HBV, HCV, or steatohepatitis.
In addition, the enhanced TRAIL sensitivity of hepatocytes from HIV-infected patients would be favored to undergo apoptosis following exposure to TRAIL expressing immune cells.
However, the relevance of upregulated DR5 expression for enhanced TRAIL DISC formation and stress-triggered sensitization of cancer cells to TRAIL-induced apoptosis is controversially discussed [41], [54], [55], as it may also result from an enhanced binding of caspase-8 to the DISC.
A concentration of 5 μM worked well for all cell lines, resulting in enhanced TRAIL sensitivity.
Similar(42)
Good positive correlation was found between those siRNAs that enhanced TRAIL-induced caspase-3/7 and those that enhanced TRAIL-induced caspase-8 activation.
Again, our findings in this article that IκBKB LOF leads to enhanced TRAIL-induced caspase activation provide support for further studies of NF-κB inhibitors in combination with TRAIL.
Two algorithms will be proposed, including Trail-based Algorithm with virtual Guide line (TAG) and enhanced Trail-based Algorithm with virtual Guide line (eTAG).
However, it also has been reported that MG-132 decreased c-FLIP levels and enhanced TRAIL-induced apoptosis in prostate cancer cells and chronic lymphocytic leukemia cells [14], [15].
These results demonstrated that salubrinal enhanced TRAIL-induced eIF2 α phosphorylation and CHOP expression.
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