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All results proved that self-targeting MTX moiety enhanced the target efficacy to potentially help the MTX-PEG-CPT NRs enter FA receptor-overexpressing HeLa cells by FA receptor-mediated endocytosis via multivalent receptor-ligand interactions [27].
Although a modest decrease in target specificity was observed, the application of the ARAi system dramatically enhanced the target specificity of the resulting inducible ClosTron method, and thus solved the problem of off-target integration.
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Thus, the authors demonstrated that the polyvalent display not only enhanced the targeting ability of the aptamer, but also imparted a novel function, cytotoxicity.
Simulation results suggest that such a target recovery can enhance the target positioning accuracy by a factor of 3 (Supplementary Note 4 and Supplementary Fig. S5).
The jury is still out on Microsoft's acquisition of LinkedIn, but there, too, the logic is to enhance the target, not fold it into the acquirer.
These unexplored drug-induced environmental changes enhancing the target electrostatics are validated against drug target affinity data, yielding superior computational accuracy required to improve drug design.
The goal is to enhance the target detection performance by suppressing the clutter and jamming based on space time adaptive processing (STAP).
This study aims to investigate the impact of a meaningful learning-based evaluation method on ubiquitous learning, in order to enhance the target system.
The procedure can not only enhance the target reflection while suppressing the noise by improving the signal to noise ratio (SNR), but also separate the background and reflection signals.
First, based on the intensity distribution of an IR image, we design a global background subtraction filter (GBSF) to suppress the background, and an adaptive row mean subtraction filter (ARMSF) to enhance the target.
The present study thus offers a process design strategy of potential industrial significance to the challenge of selectively enhancing the target product, while marginalizing other closely related co-products.
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CEO of Professional Science Editing for Scientists @ prosciediting.com