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While high Mg2+ largely enhanced the severity of the trpm larval growth phenotype, it appeared that supplementation of Mg2+ exclusively during the late-stage of larval development partially suppressed the biosynthetic defects in the fat body.
We showed that PD-1-Fc enhanced the severity of autoimmune arthritis in mice with CIA.
Bacterial coinfections were also detected and likely enhanced the severity of the enteritis disease by triggering synergistic effects.
Restoration of 5-HT in TPH1−/− mice by administration of a 5-HT precursor (5-hydroxy L-tryptophan) enhanced the severity of colitis.
In addition, administration of exogenous recombinant IL-33 impaired intestinal barrier function and enhanced the severity of DSS-induced colitis by increasing intestinal permeability, strongly suggesting that bioactive IL-33 is released locally upon injury.
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Furthermore, several toxicological studies demonstrated that PM acts as an adjuvant to enhance the severity or development of asthma (e.g., Li et al. 2009).
Repetitive exposures at the same dose will then enhance the severity of the injury because of the presence of toxic levels of the chemical in the target tissue.
Cotten, S. W. et al. Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease.
Previous studies implicated the plasmid-encoded surface protein Asc10 in enhancing the severity of experimental endocarditis in rabbits [16], [19].
Enterococcus faecalis Aggregation Substance (Asc10) protein enhances the severity of experimental endocarditis, where it has been implicated in formation of large vegetations and in microbial persistence during infection.
The severity of inflammation was augmented with arthritic PyV MT bones suggesting that the metastatic PyV MT tumor may have the potential to enhance the severity of arthritis.
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