Furthermore, R848 enhanced the efficacy of anti-PD-1 (programmed cell death protein 1) checkpoint blockade in the treatment of an anti-PD-1-resistant tumour.
In contrast, expression of a secreted form of CE (sCE2) combined with CPT-11 treatment markedly enhanced the efficacy of AdDelta24 virotherapy.
However, when combined with radiation, anti-CCR2 significantly enhanced the efficacy of tumor regression compared to IR alone (144 ± 71 vs. 540 ± 151 on day 43, P < 0.01: Student's t-test).
Importantly, H6 enhanced the efficacy of paclitaxel against KBV cancer cell-derived xenograft tumors in nude mice.
The addition of bortezomib further enhanced the efficacy of NSCs-TRAIL treated group in one of examined tumor models.
At doses between 50 and 200 mg kg−1, OISE enhanced the efficacy of acarbose by up to 5-fold.
Finally, the spray-dried MTX-loaded PLGA microparticles enhanced the efficacy of the drug in the human cervical cancer cells (SiHa cell line).
Conclusion: Adjuvant recombinant human erythropoietin safely enhanced the efficacy of iron sucrose in the treatment of gestational iron-deficiency anemia resistant to orally administered iron alone.
Specifically, exposure to ISMN significantly enhanced the efficacy of ciprofloxacin by reducing the number of CFU (~ 3log10 or ~ 2log10) of biofilm-associated and planktonic bacteria respectively, compared to drug alone.
After intratumoral injection, the hydrogel could be retained in the tumor for more than 9 days, significantly inhibited the CAFs and collagen synthesis in orthotopic 4T1 tumors, and enhanced the efficacy of PEGylated doxorubicin-loaded liposomes (Dox-L) in inhibiting the tumor growth (64% vs. Dox-L alone) and lung metastasis (80% vs. Dox-L alone).
Add-on lithium enhanced the efficacy of quetiapine XR in patients with acute bipolar I mania, without compromising safety and tolerability.
