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These two substitutions enhanced the affinity of p53 for specific DNA yet, counterintuitively, decreased the residency time of p53 on DNA.
Introducing an appropriate substituent into position-9 of β-carboline nucleus enhanced the affinity of the drug to DNA resulting in remarkable Topo I inhibition effects.
Substitution of R190 with W190 enhanced the affinity for a severe acute respiratory syndrome coronavirus peptide 6 fold but reduced the affinity for N-formyl-Nle Leu Phe by 2.5 fold.
In both the cases, the presence of additional polar moieties such as carbonyl, sulfonamide, and hydroxyl groups enhanced the affinity of the Pebax-based membranes for the penetrating species considered in this work.
By replacing three Lys residues and combining the Ala26→Arg mutation that significantly enhanced the affinity for RNA, we engineered a SacY-CAT variant that should be suitable for NMR study of the complex.
More dramatically, these same agents enhanced the affinity of the receptor by ten-fold, without affecting the specificity of the receptor.
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These interactions significantly enhance the affinity of this MOF for unsaturated hydrocarbons.
Multiple ligand presentation is a powerful strategy to enhance the affinity of a probe for its corresponding target.
Enhancing the affinity of scaffolds for endothelial cell (EC) is a crucial procedure for promoting angiogenesis in tissue engineering.
(iii) Substrate-loading from the SBP to the TMD dimer appears to enhance the affinity between the SBP and TMD (Rice et al., 2014).
Csk and the cytoplasmic domain of phosphorylated Cbp form a stable complex and enhance the affinity of Csk toward Src (Takeuchi et al., 2000).
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