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The possibility of direct nose-to-brain transport offers enhanced targeting and reduced systemic side effects.
This article synthesizes recent advances in pricing and promotions findings as they pertain to enhanced targeting, new price and promotion models, and improved effectiveness.
The engineering of future generations of nanodelivery systems aims at the creation of multifunctional vectors endowed with improved circulation, enhanced targeting and responsiveness to the biological environment.
Chemical conjugation of interferon (Suginoshita et al. 2002) and DNA (Hosseinkhani et al. 2002) with pullulan enabled enhanced targeting to the liver.
It can specifically bind to various cancer cells, and its conjugates containing anti-cancer agents exhibit enhanced targeting ability to the tumor and higher therapeutic efficacy compared to free anti-cancer agents.
When we studied the subcellular distribution of UmSRT1-GFP in response to various redox-active compounds, we observed neither a reproducibly enhanced targeting of UmSRT1-GFP to the plasma membrane and, most importantly, no formation of raft-like structures (Fig. 8).
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For example, modification of immune effector engagement has improved pharmacokinetic profiles, and conjugating cytotoxic agents to mAbs has enhanced targeted therapeutic delivery to tumors.
As our result proved, using oligoclonal nanobodies as targeting moiety enhance targeting efficacy in comparison with monoclonal VHH.
One department was particularly proud of a tool they'd developed, based on an algorithm created by the agency, which could enhance targeting in television advertising.
Varying ligand surface density also may help enhance targeting selectivity.
These cleavage site and DNA spacer sequence dependencies enhance targeting specificity yet confer moderate targeting constraints.
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