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For example, modification of immune effector engagement has improved pharmacokinetic profiles, and conjugating cytotoxic agents to mAbs has enhanced targeted therapeutic delivery to tumors.
The possibility of direct nose-to-brain transport offers enhanced targeting and reduced systemic side effects.
Chemical conjugation of interferon (Suginoshita et al. 2002) and DNA (Hosseinkhani et al. 2002) with pullulan enabled enhanced targeting to the liver.
This mechanism for localization of a multidomain protein can be used to generate enhanced targeting specificity.
Nanoparticle-based therapies offer several advantages over free drugs including enhanced targeting and reduced off-target side effects.
Enhanced targeting via multivalent binding, reporting location of action, and optimal impact at the target via delivery of a multidrug payload are important goals of theranostic design.
The results are included in a revised Figure 5, and show enhanced targeting of the promoter of the modified loci by AID but not sA3G.
MRI and histological analyses visually confirm enhanced targeting and also suggest a limited contribution of passive mechanisms to tissue retention of nanoparticles.
We have also demonstrated enhanced targeting of LMP2A in vitro following treatment of Renca-LMP2A with EtxB (Fig. 3D and E).
To enhance targeted insertion, homologous recombination was stimulated using targeted cutting at the OCT4 STOP codon with CRISPR/SpCas9.
Zooming in can provide a more specific focus, and enhance targeted awareness-raising within countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com