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Even if it is unclear whether myocardial adrenergic stimulation is the only pathophysiological mechanism associated with SRC, enhanced sympathetic tone inducing endogenous catecholamine's stimulation of the myocardium was always reported [3].
Another potential contributing factor is enhanced sympathetic activity.
It was also shown that EA stimulation significantly enhanced sympathetic activity [ 34].
Previously, we have reported that GDNF enhanced sympathetic axon growth toward cardiomyocytes [ 8].
In summary, male Pomc-Sw mice exhibited enhanced sympathetic activity in their adipose tissues.
In diseased hearts, nonuniform innervation promotes enhanced sympathetic activity and therefore life-threatening arrhythmias.
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In patients with fibromyalgia syndrome (FMS) and temporomandibular disorder (TMD), stress and pain may chronically enhance sympathetic activity, altering cardiovascular responses and worsening pain.
When NGF is bound to TrkA, the receptor transmits positive signals that enhance sympathetic neuron growth and survival.
Considering brain injury, cytokines produced in the brain after trauma as well as an increased ICP can enhance sympathetic nerve activity.
The authors suggest that an exposure to prolonged microgravity may enhance sympathetic neural traffic not only to muscle but also to bone.
It also enhances sympathetic signal transduction, which increases peripheral vascular resistance and increases baroreceptor sensitivity, which helps with orthostatic symptoms without exacerbating supine hypertension.
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