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This finding may be related to its higher response rate, resulting from tumor shrinkage, with subsequent attenuation of clinical symptoms, possibly leading to enhanced survival time.
A comparable situation was found in two out of five glioblastoma patients, both characterised by enhanced survival time, who also relapsed after surgery/chemotherapy with less aggressive recurrences.
This test is sensitive to differences in survival between treatment groups at a specific endpoint, but cannot determine whether such a difference is due to an enhanced cure rate or an enhanced survival time among uncured patients.
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RESULTS: Elimination of CIITA greatly enhanced graft survival (median survival time [MST] 36 days) over the survival of wild-type (MST 9 days) and even over Abeta (MST 20 days) cardiac grafts.
Taking into account that adjvant chemotherapy is standard since the early 1990 and the use of 5-FU did not change over time, the enhanced survival in part could also be referred due to introduction of new chemotherapeutic agents such as Oxaliplatin and biological agents [ 28– 30].
After transendothelial cell migration (TEM), leukocytes display an altered phenotype, enhanced survival, and enhanced ability to eliminate pathogens [13].
Other studies demonstrated only an initial survival advantage that disappeared with time, and concluded that no enhanced survival rates follows BRCA1 dysfunction [ 15- 17].
4 15 16 A more aggressive lifestyle modification and optimisation of medical treatment may be a plausible reason for the enhanced survival in individuals who are obese at the time of coronary revascularisation.
However, despite enhanced survival ability of iNANOG cells, many injected cells died over time.
On the other hand, the expression of complement inhibitors by tumor cells has also been associated with enhanced tumor progression manifested by larger tumor size, lower differentiation rate, shorter survival time and shorter remission [ 19, 20].
While theoretical work on nonlinear maps29 and on predator-prey systems30 has linked perturbed within-patch population dynamics to enhanced survival, experimental validation is lacking owing largely to difficulties in obtaining high-quality time series data.
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