For a more comfortable visualization of the local receptor distribution within the sections, the linearized images were contrast enhanced, smoothed, and pseudocolor coded in a spectral sequence (Fig. 2 E ).
Moreover, PDGF-BB that was strongly bound to the heparin-conjugated scaffolds enhanced smooth muscle cell (SMC) proliferation.
ELP4 surface modified materials demonstrated enhanced smooth muscle cell (SMC) adhesion and maintenance of cell numbers over a 1-week period relative to controls.
Remarkably, fibrous structure and physiologically relevant stiffness of hydrogels cooperatively enhanced smooth muscle contractility and pharmacological responses to vasoactive drugs at both the single cell and intact tissue levels.
Incorporation of GRGDS into the high crosslink density elastomer also enhanced smooth muscle cell proliferation, while proliferation on the low crosslink density unmodified, base etched, and PEG-GRGDS incorporated elastomers was significantly greater than on the high crosslink density unmodified and base etched elastomer.
This work indicated that BM-MSCs enhanced smooth muscle regeneration in tissue engineered bladder.
These data go some way towards supporting the notion of enhanced smooth muscle NO responsiveness as a consequence of deconditioning.
The underlying cause of systemic hypertension in diabetes is thought to be peripheral vasoconstriction [ 4] mediated, at least in part, by endothelial dysfunction [ 5, 6] and enhanced smooth muscle contractility [ 7].
Additionally, people with diabetes are known to have disproportional reactive oxygen species formation, which has been associated with increased tissue damage (Maritim et al. 2003) and enhanced smooth muscle tone (Stocker and Keaney 2004).
Another study suggested that this antioxidant capacity and cholesterol lowering effect observed in the hypercholesterolemic restenosis New Zealand white rabbit model fed with 80% ethanol extract of Danshen treatment (4.8 mg/kg/day, 6 weeks) enhanced smooth muscle apoptosis and attenuates neointimal hyperplasia [ 132].
