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In terms of molecular evolution, DNA methylation has been reported to remarkably increase the rate of spontaneous C-to-T mutations at CpG dinucleotides (Ehrlich and Wang 1981; Hwang and Green 2004; Mugal and Ellegren 2011), resulting in enhanced sequence divergence.
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The magnitude and overall aspect of enhanced mitochondrial sequence divergence in Geraniaceae – different levels of divergence according to taxonomic group within the family – mirrors the pattern seen within Plantago (Fig. 2) [ 17].
The aim of this current study was to identify unique strain differences using a genome wide approach, with a view to both gaining greater insight into enhanced virulence and as a means of identifying regions of sequence divergence suitable for use as diagnostic indicators of hypervirulence.
Because S605P and I978V are located in an ORF1 region that has high sequence divergence, they are unlikely to be responsible for an enhanced disease-inducing capacity.
The bar indicates 1% sequence divergence.
The bar represents 20% sequence divergence.
The scale bar represents 5% estimated sequence divergence.
The scale bar indicates 5% estimated sequence divergence.
Data reported here also indicate high levels of sequence divergence within Glyphorynchus.
Protein functional annotation relies on the identification of accurate relationships, sequence divergence being a key factor.
Sequence divergence between the Northern and Southern European clade was 9-18 base pairs, and sequence divergence to the outgroup F. fasciatus was 41-62 base pairs.
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