In addition, microparticle stimulation of DCs also enhanced secretion of the cytokines IL-12p40 and IL-6, a phenomenon found to be dependent on polymer chemistry.
On the other hand, introduction of the polar amino acid asparagine into the C-terminal region enhanced secretion of the recombinant proteins.
Canellas et al. [11] reported changes in maize exudation profiles after humic acid application that included enhanced secretion of inorganic ions (i.e., H+ ions) and short-chain organic acids [12].
DIM was also able to suppress the estrogen induced enhanced secretion of MMP-2 as well as MMP-9 suggestive of its anti-estrogen like ability.
Although use of polycations enhanced secretion of mucin, effects were not as striking as those observed with chrysotile.
Such alterations become pro-oncogenic when enhanced secretion of cathepsins initiates proteolytic pathways that increase neoplastic progression.
Enhanced secretion may impose an additional load on the ER actively engaged in lipid droplet synthesis [ 55].
We demonstrated that hypoxia preconditioning significantly enhanced secretion of angiogenic factors from MSCs, which significantly contributed to the superoxide scavenging, angiogenesis, and antiapoptosis of MSCs in injured kidney.
In the same study, using in vitro synovial membrane cell cultures, we demonstrated enhanced secretion of the proangiogenic protein vascular endothelial growth factor (VEGF).
Heterodimeric S100A8/S100A9 enhanced secretion of IL-6, ICAM-1, VCAM-1 and MCP1 in AGE-albumin pretreated HUVEC in a dose dependent manner.
Pharmacological inhibition of PRKCD enhanced secretion downstream of GPVI receptor but diminished secretion downstream of PAR (thrombin) receptors (Murugappan et al, 2004).
