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By use of the rationally designed BB aptamer-cDNA probe, a TISD based EA sensor against ATP with significantly enhanced response rate (with a displacement equilibrium time of 4 min) and high sensitivity was successfully constructed.
Telephone reminders, partly with direct telephone interviewing, enhanced response rate to the first module, but were essentially redundant in subsequent modules.
Personal contact with participants prior to sending out a questionnaire may have enhanced response rate, since many of the men who initially saw obstacles in the telephone survey actually participated in the questionnaire survey.
Nevertheless, reducing the respondent burden of an assessment can result in benefits such as an enhanced response rate [ 11], including among members of compromised subgroups [ 10].
For example, bevacizumab in combination with metronomic cyclophosphamide resulted in 56% of 70 platinum-resistant patients remaining alive and progression free at 6 months, suggesting an enhanced response rate (P=0.017) (Garcia et al, 2008).
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Despite promising preclinical efficacy results, monotherapy nanomedicines have failed to produce enhanced response rates over conventional chemotherapy in human clinical trials.
The rationally engineered synergically stabilized aptamer-cDNA duplex probes are sensitive and exhibit significantly enhanced response rates (with target binding equilibrium times of 1 min for ATP and 2 min for cocaine).
Other limitations included the lack of a comparison group to establish whether our personal survey method enhanced response rates.
This study did not identify enhanced response rates when comparing the households panels provided with choice compared to households who were only allowed to respond by mail [ 5].
6– 9 Both studies concluded that the administration of bevacizumab plus CT enhanced response rates (RR) and progression-free survival (PFS) with statistical significance.
There are several other examples of monotherapy nanomedicines that fail to produce enhanced response rates over conventional chemotherapy in clinical trials despite promising preclinical efficacy results in animal models.
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