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Other genes identified in the screen, including two alleles of Topoisomerase 3-alpha (Top3α ), while also required for developmental growth, appear to have an enhanced requirement during compensatory growth.
Our analysis has identified up-regulation of genes associated with xenobiotic metabolism/detoxification in CIS and invasive SCC relative to bronchial epithelium and precancerous lesions, implying an enhanced requirement for protection against electrophile and/or oxidative stress upon the transition from precancer to CIS.
One might speculate that replication through the telomere would disrupt its capping function and therefore capping must be reassembled thereafter, creating a time-restricted situation of enhanced requirement for capping and hence Cdc13 complex function.
Furthermore, androgen withdrawal has previously been shown to enhance expansion of Treg and naïve T-cell populations, leading to protection from disease in an EAE mouse model 37. Thus, this expansion of Treg in CSX mice is likely to reflect the enhanced requirement for regulated pathology following restoration of the Th2 immune response.
A possible mechanism for the selective cytotoxicity for compound 1 towards cancer cells over normal cells could be due to the enhanced requirement for STAT3 activity in cancer cells, leading to a greater reduction in cell proliferation upon inhibition of STAT3 signaling by compound 1.
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"Enhanced requirements are needed not only to protect the stability of individual institutions and the financial system as a whole, but also to reduce the incentives for financial firms to become very large in order to be perceived as too big to fail," he told lawmakers.
In the past few decades exponential increase in the amount of software used in cars has been recorded together with enhanced requirements for functional safety of their embedded software.
Its provisions cover all employees who receive incentive-based compensation, with enhanced requirements for individuals referred to as senior executive officers and significant risk takers.
The committee suggests that "part of the response" could be for the government to require "enhanced security requirements and background checks for those with access to large pools of personal data".
This kind of cancer requires autophagy to maintain a pool of functional mitochondria necessary for enhanced energetic requirements of tumoral cells [ 83, 85].
While no part of the 2004 intelligence overhaul would have prevented the attacks on its own, provisions like the enhanced reporting requirement could "close the loopholes that would allow future attacks of a similar design," according to the notice from the financial crimes network.
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