As for specific immunotherapy, the authors report enhanced recurrence-free survival, but data on overall survival are lacking due to the short follow-up period.
We therefore tested the hypothesis that nitrous oxide administration during colorectal cancer surgery enhances recurrence risk.
When aberrantly activated, Hh signalling mediates carcinogenesis and induces aggressive cancer phenotypes, enhancing recurrence, metastasis and chemotherapy resistance.
They concluded that the dysregulation of HIF-1 α in apparently nonmalignant liver tissue provides a modulated environment that potentially enhances HCC recurrence after curative resection [ 87].
One of the most commonly cited fears was that pregnancy may enhance cancer recurrence (Dow, 1994; Siegel et al., 1997; Braun et al., 2005; Connell et al., 2006; Gorman et al., 2011; Lee et al., 2011; Ruddy et al., 2011).
Also, since the inflammatory microenvironment allows cancer cells to survive, proliferate and make the cell genome unstable, it is possible that the inflammatory microenvironment could also enhance the recurrence of tumors after primary resection.
These studies illustrated that surgical trauma enhanced locoregional tumour recurrence and that this phenomenon involved a dose response relation, that is, severe trauma was associated with a higher locoregional tumour recurrence rate compared to mild trauma (Busch et al, 1993; Bouvy et al, 1997; van den Tol et al, 1998; van Rossen et al, 1999, 2000).
Resembling temozolomide, also, the sensitivity against anthracyclines tended to be enhanced in the recurrence-derived sublines with the strongest differences observed in case of doxorubicin.
In addition, advances in imaging have led to improvements in the preoperative staging of cancer and enhanced surveillance for tumour recurrence including improvement in tumour recognition.
The potential prediction of early recurrence is enhanced upon determining the coexpression of COX-2 and cytoplasmic survivin, as no cases that expressed neither protein in this series recurred within 5 years.
