A rationale for enhanced strain rate sensitivity is presented, but this topic will be explored in greater detail in future papers.
The results provide a chemical rationale for enhanced activity in certain cyclic antimicrobial peptides and can be used as a guideline for design of novel antimicrobial peptides.
This site is not phosphorylated in Hsp70 E. coli and, together with the multiple acetylation sites, provides a plausible rationale for the enhanced stability of the Hsp70Sf9 dimer.
In addition, there is a strong mechanistic rationale for an enhanced activity of vascular-damaging agents when combined with antiangiogenic drugs (Shaked et al, 2006).
There appears to be no obvious "direct" interactions of IsdH linker region with Hb that could provide a rationale for the enhanced heme transfer effect observed, yet clearly the N1-linker region of IsdB must be imparting a certain degree of structural strain on Hb to facilitate heme release and/or to increase the rate of heme dissociation from Hb upon complex formation with IsdB.
These specific guest-framework interactions provide a clear rationale for the greatly enhanced adsorption of C2H2 over CO2, particularly at low pressures.
These findings bring about a design rationale for membrane materials with enhanced stability against hydrolysis.
Together with a computer-aided interpretation of existing structure-activity relationships of Amaryllidaceae alkaloids congeners, we provide a rationale for designing molecules with enhanced potencies and reduced toxicities.
Regardless of the cause, this distress may have been lessened with enhanced education and continued reinforcement of the rationale for these measures and outreach efforts to optimize coping with the stressful event.
This enhanced understanding of tumor biology has provided the rationale for the design and development of novel agents that are directed against important targets, including growth factors, receptors, and tumor-specific/tumor-selective antigens.
The rationale for developing better protein therapeutics with enhanced efficacy, greater safety, reduced immunogenicity or improved delivery comes from the convergence of clinical, scientific, technological and commercial drivers that have identified unmet needs and provided strategies to address them.
