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Exact(17)
The present findings indicate that p16 enhanced radiosensitivity via increased cell death, and that this enhancement did not depend on p53 status.
However, when the 90th percentile value of 160 aberrations per 100 cells for the partner control group was used as the cutoff point for increased radiosensitivity, 13, 4 and 18% of the partner control, cancer survivor and offspring groups, respectively, were classified radiosensitive, while no individual from the WRI control group displayed enhanced radiosensitivity.
While plating efficiencies were not significantly affected by PINCH1 silencing (Table 2), the PINCH1 knockdown resulted in a significantly (P<0.01) enhanced radiosensitivity of Poly-S grown HTB43 (Fig. 5A) and HTB35 (Fig. 5B) cells relative to siRNA controls.
Three of the six cases of Wilms' tumour also displayed enhanced radiosensitivity.
Both proteins significantly enhanced radiosensitivity to a similar degree in the tested pancreatic cancer cell lines when depleted using siRNA.
Treatment with celecoxib enhanced radiosensitivity of glioma stem cells and suppressed the expression of angiogenic and stemness-related genes [ 53].
Similar(43)
Recent studies that have investigated GNPs as a radiosensitizer usually focused on kV radiosensitization, while GNPs have also been reported to enhance radiosensitivity with MV photons and electrons in breast cancer cells [31].
To demonstrate that the GNCs can enhance radiosensitivity, we carried out a clonogenic survival assay.
Therefore, novel therapeutic agents are urgently needed to enhance radiosensitivity so as to improve the outcome in these patients.
AS exhibited potential ability to enhance radiosensitivity of human NSCLC A549 cells by increasing the NO level within irradiated A549 cells [42].
GNPs have been observed to enhance radiosensitivity by regulating cell cycle and increasing the level of reactive oxygen species (ROS) [35].
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