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Finally, bladder cancers harboring a beta-catenin mutation may represent aggressive biological behavior with enhanced proliferating activity [ 44].
In Burkitt lymphoma, the tumorigenesis is mainly mediated by t(8 14) translocation involving c-MYC and IGH@ genes, leading to the extremely enhanced proliferating capacity with very short-doubling time in B-lymphoid cells (Swerdllow et al, 2008).
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The synthesis and expression of PCNA are enhanced in proliferating cells including those that are tumour-derived.
In response to injury, the Wnt/beta catenin signaling pathway is enhanced in proliferating NG2 chondroitin sulphate proteoglycan positive cells undergoing differentiation to NG2 glia [ 109].
Instead, immunity is life: 'Rather than arguing that power becomes 'joined' to life, the term 'immunity' will enable us to describe the concurrently enhancing and proliferating, and toxic and auto-negating properties of the 'power to preserve life" (2008: 46).
The augmented cell death in tumors is due to differential cell proliferation between tumors and normal tissues, and Ad replication is enhanced in rapidly proliferating cells rather than in static cells.
The importance of IMPDH and the de novo purine biosynthetic pathway in cellular metabolism stems from observations that both mRNA expression and IMPDH activity is significantly enhanced in actively proliferating cell types such as sarcoma and leukemic cells, ovarian tumors, and mitogen activated peripheral blood lymphocytes.
Together these studies clearly revealed that both Wnt/β-catenin and Notch signalling pathways are enhanced in undifferentiated, proliferating and potentially migrating HPCs during severe progressive canine liver disease (LDH).
In rodents, neurogenesis induced by global or focal ischemia is basically characterized by i) enhanced progenitor proliferation ii) migration of proliferating cells into damaged areas and iii) differentiation.
The third-passage hUCMSCs induced by conditioned medium from developing tooth germ cells (TGC-CM) displayed high alkaline phosphatase (ALP) levels (P < 0.001), an enhanced ability to proliferate (P < 0.05), and the presence of mineralized nodules.
Furthermore, it is possible that AF-induced myocyte dedifferentiation may actually facilitate myocyte regeneration in light of evidence that dedifferentiated adult myocytes exhibit downregulation of cell cycle inhibitors and reexpression of cardiac progenitor cell markers, collectively contributing to an enhanced ability to proliferate and form new myocytes [ 62, 63].
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