Sentence examples for enhanced potency for from inspiring English sources

This may be achieved by identifying compounds with enhanced potency for the inactivated state of Cav2.2.

This screen yielded 15 compounds with enhanced potency for SIRT2 inhibition and 11 compounds having SIRT2 inhibition equal to reference compound AK-1.

The objective was to identify prodrugs with enhanced potency for NFκB inhibition, reduced cytotoxicity, and selective targeting of breast CSCs, which together would indicate a favorable therapeutic index.

We suggest that the enhanced potency for the chimeric compounds compared with (R)- 2 and (S)- 3 was derived from the synergy gained by judiciously combining, within a single agent, key structural units from two compounds that show moderate inactivation properties.

Enhanced potency for depletion of total cellular glutathione was also observed for several ROS-enhancing compounds when paired with BSO.

Although structural analysis confirmed formation of these bonds, the inhibitor exhibited only mildly enhanced potency for GRK2 and exhibited less selectivity relative to PKA and PKC.

It can be concluded from our data that 1,9-diarylnona-1,3,6,8-tetraen-5-one can serve as a new potential scaffold for the development of anti-prostate cancer agents and that pyridine-4-yls and quinolin-4-yl act as optimal heteroaromatic rings for the enhanced potency of this scaffold.

The main finding to emerge from the present in vivo study goes some way to offer an explanation for the enhanced potency of 2-MeOE2 bisMATE.

Therefore, IFN-γ-induced activation rather than altered surface expression levels of CD317 may account for the enhanced potency of the immunotoxin HM1.24-ETA′ on IFN-γ-activated monocytes.

These findings suggest that increased Ca2+ store loading and subsequent release is likely to be responsible for the enhanced potency of UTP in MSMC isolated from 12-wk-old SHR.

Additionally, our finding regarding the enhanced potency of outer meniscus cells (compared with inner meniscus cells) to suppress hypertrophic differentiation of MSCs makes it an attractive cell source for the reconstruction of the inner meniscus.