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Consistent with observations of the influence of saeR/S on murine mortality during S. aureus bacteremia [18], [33], saeR/S-regulated factors significantly enhanced morbidity and mortality in the peritonitis model (1 mouse infected with MW2 survived the 72 hours time course, compared to 8 mice infected with MW2ΔsaeR/S; P<0.001; figure 1F).
Nevertheless, NOS2 mice display enhanced morbidity and mortality after administration of endotoxin or TNF.
Morbid obesity is associated with significant morbidity and mortality including enhanced morbidity from cardiovascular, cerebrovascular, hepatobiliary and colonic diseases.
Insulin resistance often characterizes chronic uremia, and is associated with enhanced morbidity and mortality, because it may contribute to protein-energy wasting (in turn, an independent predictor of reduced survival), atherosclerosis, and cardiovascular death.
These prognostic indicators of enhanced morbidity are driven by a common feature of HNC lesions known as field cancerization.
Intranasal infection of B6.RAG or B6.RAG-2γc−/− mice with 105 PFU of BJx109 does not induce weight loss or disease and BJx109-infected B6.RAG-2γc−/− mice treated with mAb 1A8 did not show enhanced morbidity (MT and PR, unpublished observations).
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This balance is important because elevation of the interstitial fluid may enhance morbidity and mortality by increasing the length of stay and mechanical ventilation time.
In addition to reducing quality of life and enhancing morbidity, disability, and premature mortality (4, 5), diabetic foot complications are a considerable financial burden on society and individual patients (6), accounting for ∼20% of the total expenditure on health care for patients with diabetes (1).
Accordingly, MYD88 deficiency in humans is associated with increased susceptibility to pyogenic bacterial infections and Myd88-deficient mice have enhanced susceptibility and morbidity to most viral and bacterial experimental infections.
Preservation of the frontal sinus (FS) during the frontolateral approach to the skull base reduces morbidity, enhances patient comfort, and speeds up the surgical procedure.
Patients suffering from diabetes show a disturbed wound-healing process that may enhance the overall morbidity and mortality of this population [ 1, 2].
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