Sentence examples for enhanced malignant potential from inspiring English sources

Therefore, age-dependent mechanisms that regulate DNA integrity and DNA damage responses may provide clues to reconciling the co-existence of senescence and enhanced malignant potential.

Level of Id protein expression, especially of Id1, correlates with poor differentiation, enhanced malignant potential and more aggressive clinical behaviour of ovarian tumours.

Level of Id protein expression, especially of Id1, correlates with poor differentiation, enhanced malignant potential and more aggressive clinical behaviour of epithelial ovarian tumours (Schindl et al, 2003).

The level of Id protein expression correlates with poor differentiation, enhanced malignant potential, aggressive clinical behaviour of different tumours, including epithelial ovarian tumours, and is a strong predicator of shorter survival (Schindl et al, 2003).

It is also important to note that we found evidence of a sustained inflammatory milieu in lesions in Mmp8-null and Mmp8-heterozygote mice, resulting in higher expression of proinflammatory mediators IL-6 and LIX/CXCL-5 at the end stage of the MMTV-PyMT model, which may also contribute to enhanced malignant potential.

Moreover, cells undergoing EMT display cancer stem cell-like properties that are associated with enhanced malignant potential and progression [19].

These cells are proposed to display enhanced malignant and metastatic potential [ 6– 8].

Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT) features display enhanced malignant and metastatic potential.

Expansion or imbalance in the dNTPs pool would increase the DNA mutation rates [ 5], which could potentially enhance the malignant potential of cancer cells.

To this point, overexpression of Oct4 is sufficient to induce dysplastic growth in adult mouse epithelium [22] and enhance the malignant potential of ESC-derived germ cell tumors [19].

Overexpression of Oct4 enhances the malignant potential of ESC-derived tumors, while inactivation decreases malignant potential [44 46].