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In the animal world they can win something even more precious an enhanced life span.
Co-incubation of PMN with purified S. aureus LTA was shown to activate PMN leading to enhanced life span [ 2].
Another age-induced miRNA, namely miR-34, did not affect C. elegans life span in one study (de Lencastre et al, 2010) but its inhibition enhanced life span by regulating autophagy in another study (Yang et al, 2011).
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The thrombocytopaenia in BCL-2tg and Bak−/− BCL-2tg mice is at odds with the enhanced platelet life span in these animals.
Furthermore, antioxidant molecules traditionally cause enhanced neutrophil life span by delaying neutrophil apoptosis (59, 60), while production of neutrophil ROS is associated with the induction of neutrophil apoptosis in a variety of experimental situations (61).
Accordingly, interventions that limit WAT enlargement are associated with enhanced health and life span [ 6].
Excess or dysfunctional fat tissue appears to accelerate onset of multiple age-related diseases, while interventions that delay or limit fat tissue turnover, redistribution, or dysfunction in experimental animals are associated with enhanced healthspan and maximum life span.
The extended life span and enhanced phagocytic activity of PMN can contribute to a more efficient resolution of the infection.
Moreover, forced telomerase expression in hMSCs led to an extended life span and enhanced differentiation potential (Simonsen et al, 2002).
Animal experiments indicate that CD22 plays a key role in B cell development and survival, with CD22-deficient mice having reduced numbers of mature B cells in the bone marrow and circulation, and with the B cells also having a shorter life span and enhanced apoptosis [ 31].
Significant advances have been made in the treatment of patients with haemophilia, resulting in reduced mortality, improved joint outcomes, enhanced quality of life, and extended life span.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com