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The method included a newly designed hydrolysis probe to enhance its specificity.
There is thus an urgent need to supplement PSA with novel biomarkers that enhance its specificity so that unnecessary biopsies can be avoided.
The yeast system requires extensive work to enhance its specificity, and the bacterial systems yield many false results due to translation re-initiation events occurring post PSCs.
Together, these results established that the activity of an E3 ubiquitin ligase can be safeguarded by an accompanying deubiquitinase to enhance its specificity.
Consequently the reaction of MitoB with H2O2 should be faster in the mitochondrial matrix (pH ∼8.0) compared to the cytosol (pH ∼7.2), further enhancing its specificity for mitochondrial H2O2.
The anti-CCP antibodies have been shown to be more specific than the rheumatoid factor (RF) for diagnosing RA and possibly better predict radiographic progression of joint erosion (category C) [ 15]; anti-CCP testing has been incorporated into the new EULAR classification criteria to enhance its specificity for early disease [ 7].
It is possible that the local adaptation of the SRQ-20 may have enhanced its sensitivity and specificity.
In this model, a DUB can cooperate with an E3 ligase to enhance its substrate specificity.
Our studies provide new insights into the basis for potentiated Hsp104 activity against a diverse array of substrates and provide clues as to how potentiated Hsp104 might be fine-tuned to enhance its substrate specificity.
In this study, we inserted a nonpairing bulge at the 5' end of the "10 23 DNA enzyme" to enhance its efficiency and specificity.
Those data suggested a unique mechanism designed by nature that utilizes a protein's negatively charged C-terminal tail to enhance its DNA-binding domain's specificity to certain structured DNAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com