To obtain increased therapeutic efficacy, a drug carrier must achieve increased delivery of the drug to the tumor tissue, while also allowing for enhanced interaction of the drug with, and subsequent internalization by, tumor cells.
Its idea for "enhanced interaction" (code for discussing problems that affect the neighbours) is no longer considered quite so heretical.
It may be that the greater hydrophobic nature of the ethyl group of STX243 (with respect to the methoxy group of STX140) allows for enhanced interaction with the colchicine-binding site on tubulin, with which STX243 is presumed to interact, and thus delivers the observed increase in antiproliferative activity in vitro (Leese et al, 2005).
Dynamical evolution can lead to an enhanced interaction rate for compact binaries in dense stellar systems and a distinct and richer population of compact binaries.
The site's basic infrastructure needs to be improved to allow continued excavations, access for tourists and enhanced interaction with the local community.
Overall, these data supported an activating role of p.Val55Met through enhanced GDP release as a result of a decreased affinity for the nucleotide and/or enhanced interaction with a GEF.
Likewise, strongly enhanced interaction with negatively charged model membranes was found for the LFchimera relative to the constituent peptides.
In the R2240-R2240 channel, vdW repulsions are compensated for by electrostatic contributions rendered favourable through enhanced interaction with the carbonyl moieties of the selectivity filter.
Within the complex, PHD2 exhibits increased hydroxylase activity towards HIFα, resulting in enhanced interaction between HIFα and VHL, owing to the higher affinity of VHL for hydroxylated HIFα.
Nitrogen-doping allowed for a stronger polysulfide absorption in the interwoven N-doped graphene sheets because of the enhanced interaction between nitrogen heteroatoms and polysulfides [145].
The hydrophobic ϕ linking group may increase secondary interaction with hydrophobic domains near the HA binding site, leading to enhanced interaction with the glycan receptor (33).For 33-ϕ-OEG-lipid and 32-ϕ-OEG-lipid, the difference is only in the third sugar unit.
