Moreover, patients with high levels of macrophages in TIF showed a significantly enhanced incidence of local tumor recurrence (ρ = 0.0001).
Groups of mice were vaccinated with 100 µg of MBP-C5a or PBS emulsified in CFA, s.c. on day −21 and revaccinated on days −10 and −2 with 50 µg of MBP-C5a or PBS emulsified in IFA s.c. A cocktail of the 3 mAbs (6 mg per mouse) was injected i.v. and on day 5, LPS (25 µg/mice) was injected i.p. to enhance incidence and severity of arthritis.
It is well known that increased cancer detection activities, notably mammographic screening examinations, may enhance incidence rates (Persson et al, 1993; Wun et al, 1995; Rostgaard et al, 2001).
Coupling of TgPTTG with mutant p53 led us to conclude that the early neoplastic events (normal to dysplastic) were independent of p53 as the additional mutation did not enhance incidence of ovarian cancer; however overexpression of PTTG and loss of p53 function reduced the time of development of certain cancers, including sarcoma.
However, the addition of cisplatin significantly increased apoptosis in BMI-1 knockdown cells, suggesting that combining BMI-1 inhibition with cisplatin enhanced the incidence of apoptosis.
We previously reported that LA enhanced tumour incidence, volume, and number in a peritoneal metastasis model of gastric carcinoma.
We hence asked whether the absence of EphA3 enhanced the incidence of p53-loss-driven lung cancer progression.
In our animal model, prednisone administration enhanced the incidence of the disease in up to 75% (6/8) of the male WKY rats, suggesting it is a suitable model.
Heterozygous Pten +/− mice display various hyperplasias and even Pten hypomorphs with a 20% reduction in PTEN protein expression display enhanced tumor incidence, indicating that subtle reductions in the dose of PTEN predispose to tumorigenesis (Alimonti et al., 2010).
Patients with RA were also shown to experience a markedly enhanced cumulative incidence of silent myocardial infarction (MI) and sudden death as well as heart failure; the latter is strikingly often with preserved ejection fraction [ 1].
