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The example in Fig. 2 demonstrates an enhancement of the FD within the peripheral parts of a soft-tissue tumour of the upper leg on the parametric image of the FD, which indicates enhanced heterogeneity in this part of the tumour.
Clinically, mutator lineages will lead to enhanced heterogeneity within tumors, enhancing the probability that a sub-population of tumor cells manifests pre-existing resistance to therapy.
This variation could have contributed to the degree of virulence even within the same clonal genotype and enhanced heterogeneity in the infection potential.
Thus, effects of the N588K mutation on current during the PF AP were small for co-expressed hERG1a/1b (smaller than for hERG1a alone under identical conditions [12]), consistent with enhanced heterogeneity in repolarizing IKr between ventricular and PF APs in SQT1.
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Such a heterogeneous distribution might enhance heterogeneity in some areas and reduce it in other areas.
This will enhance heterogeneity effects in any subsequent meta-analysis.
These variations contribute to the drawbacks of any subsequent MAs, as they will enhance heterogeneity effects.
Moreover, different ethical decisions related to active treatment for extremely preterm births might enhance heterogeneity between countries in obstetricians' decisions to choose cesarean delivery [ 39, 40].
The sample size was deliberately large to enhance heterogeneity, and we had multiple, small snowball chains with initial selection guided by an informal quota [ 13].
Although gene conversion can contribute to the generation of new MHC class I alleles by shuffling DNA sequence motifs, thereby enhancing heterogeneity, the very same mechanism can also result in homogenisation of sequences within a multigene family.
Additionally, a diagnostic procedure invariant to age, gender, and informant, as used in the IMAGE study, may have enhanced the heterogeneity in the proband sample.
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