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Elevated heart load goes along with enhanced forces during cardiomyocyte contraction due to cell stretching and therefore increased sarcomere lengths as force generating subunit of myofibrils from originally ∼1.9 µm to extended lengths of up to 2.4 µm (Rassier and Pavlov, 2010).
The effect on degree of mineralization may be more complex, since enhanced forces stimulates bone growth and remodelling [ 12, 39] and hence may increase the degree of mineralization, at least in young animals [ 10].
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Such an arrangement of contractile proteins could contribute to the slower shortening velocity and enhanced force-generating ability of smooth muscle.
Also, enhanced force production could be related to the greater amount of time that the cross bridge spends in the attached, high force-producing state (i.e., duty cycle).
However, whether resting FC is altered in the recovery period after enhanced force is unknown.
Application of Ca2+ and epinephrine, as well as electrical stimulation or stretching, resulted in enhanced force development.
Its periodic waved structure introduces cyclical variation of local flow direction, local flow velocity and local pressure, thus leading to enhanced forced-convection.
Grafting TPA onto polysiloxanes was employed as a strategy to ameliorate the thermal stability and cycle stability of the electrochromic properties due to the enhanced force of adhesion between the polymer films and the ITO substrate.
Thus, higher amplitude values of MP in CHG might be caused by the enhanced force implicated by more muscle contraction and precision.
While insulin supplementation was not completely necessary, it significantly enhanced force production (>2 fold) compared to differentiation without insulin.
Such a regulatory mechanism would therefore be an ideal system to respond instantaneously to environmental changes or just stress factors causing temporal tissue stiffening connected with the necessity of enhanced force values.
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