Of course, reducing the cell-sizes means increasing the number of BSs in an area, which is generally rejected due to the enhanced infrastructure expenses.
In some circumstances, the impaired CYP2D6 activity actually enhances the drug effect, but perhaps at the expense of enhanced toxicity.
However, it has the additional advantages of a simplified design, the elimination of the membrane (a significant component expense) and enhanced fuel and catalyst utilization through the extension of the active catalyst zone.
Here, we show that access of Bacillus Calmette Guérin (BCG) to the bone marrow (BM) changes the transcriptional landscape of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs), leading to local cell expansion and enhanced myelopoiesis at the expense of lymphopoiesis.
Thus, the beneficial effect of IL-2 or IL-15 appeared to occur at the expense of enhanced background activation of T cells.
However, the steady-state of FLPe protein level is 3 times of wild type FLP in mammalian cells, indicating that the higher recombination efficiency observed with FLPe is largely due to its enhanced thermostability in the expense of lower enzymatic activity.
However, while tumour resistance to BCNU was overcome using BG, this was at the expense of enhanced bone marrow, gut and liver toxicity.
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A different orange fruit (Beta mutant) produces enhanced β-carotene levels at the expense of lycopene.
Enhanced accumulation of squalene at the expense of other sterol intermediates has previously been reported in S. cerevisiae treated with the squalene epoxidase inhibitor, terbinafine [ 27].
