Non-neoplastic mucosa from the DMH-treated animals requires an enhanced dose of vincristine of 1.5 times, compared with normal mucosa, to achieve a PMI of 1%.
The discrepancy remains unexplained, but still suggests that the need for enhanced dose intensity of oxaliplatin above 85 mg m−2 requires exploration.
Such materials can provide several advantages such as a high-packing density, which can lead to enhanced dosing, an increased flexibility of design as these materials naturally interact biologically and a lack of void volume as whole particles can be designed to be active.
Increased free radical production at various doses of DEP would result in impairment of the defense system leading to an enhanced dose-dependent reproductive toxic effect.
These results indicate that mice lacking both Slo2.1 and Slo2.2 channels exhibit an enhanced aversion to moderate doses of capsaicin and that Slo2 dKO can influence the acute response to sensory stimuli.
In order to account for degradation of the prescribed dose gradient at the edge of moving target volumes during delivery, patient-specific margins that consist of edge-enhanced dose intensity maps can be constructed[85].
The enhanced ability of relatively low doses of amifostine to inhibit spontaneous metastases formation suggests that effective antimetastatic therapies with amifostine can be designed with minimal toxic side effects.
Results: Systemic administration of increasing doses of leptin enhanced DNA content when compared with the appropriate control (group 2, 1.06 [plusmn] 0.04 [P [lt ].05]; group 3, 1.1 [plusmn] 0.05 [P [lt ].01]; and group 4, 1.07 [plusmn] 0.06 [P [lt ].05].
Carraguard showed limited activity against cell-free and mature DC-driven RT-SHIV infections and, surprisingly, low doses of Carraguard enhanced infection.
In the C2C12hE50 cells, the enhanced exon skipping with increasing doses of hE50AO24PMO exhibited as both increased number of GFP positive cells and the intensity of the GFP signals within the cells (Figure 3C).
