Sentence examples for enhanced disruption from inspiring English sources

Although loss of a single copy of the polarity mediator and known CagA interactor, par 1, did not cause a discernible eye epithelium phenotype by itself, par1 flies expressing CagA displayed enhanced disruption when compared to eye epithelia expressing only CagA (Table 1).

Because this enhancement in signal attenuation correlates with an enhanced disruption of previously observed higher order oligomers of HER3 receptors [ 11], this may provide a glimpse into the additional control mechanisms that act upon RTK receptors on the level of higher order association states, which arguably is one of the least understood aspects of RTK signaling at this point.

When hGSK3β expression was driven together with 2N4R Tau inserted in the 68A locus an enhanced disruption of the eye occurred (Fig. 4A, lower panels).

The synergistic action of trastuzumab and pertuzumab combination treatment was previously shown in vitro to be mediated by enhanced disruption of receptor dimers, leading to increased apoptosis (Nahta et al, 2004a).

Over expression of Aurora kinase B has previously been found to interfere with chromosome bi-orientation and the spindle-assembly checkpoint due to enhanced disruption of kinetochore-microtubule attachments and sister chromatid cohesion [ 39].

Specifically, blood-derived leukocytes are the primary sources of this damage, and infiltration of systemic immune cells results in enhanced disruption of the blood-brain barrier (BBB), leading to increased cerebral edema and subsequent deterioration of neuro-behavioral function [ 5- 7].

Unclear responsibilities enhance disruption.

The ratio for non-phosphorylatable Hts was significantly higher when compared to wild-type Hts, indicating that blocking phosphorylation of Hts enhances disruption of Dlg postsynaptic targeting.

In this respect, we have previously shown that endothelial tight junctions are disrupted in cells treated with recombinant purified granzyme B. This was the main rationale for testing whether granzyme B can also cleave MAGUKs, thus enhancing disruption of the cell contacts and facilitating phagocytosis of the target cells.

Eclipse time (the time from infection of a cell to the first intracellular appearance of infectious progeny) was measured by infecting cells in the fitness assay environment and extracting undiluted samples over chloroform at one-minute intervals; the cells were subjected to freeze-thaw before plating to enhance disruption of cell integrity.

Furthermore, Gab2, but not Gab2Δp85, significantly enhanced acinar disruption induced by the hyper-active v-Src and c-SrcY527F mutants [ 94].