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After rolling on E-selectin, the densely immobilized antibodies through dendrimers can exploit multivalent binding effect, which allows significantly increased strength of surface binding with cells and thereby enhanced detection sensitivity using blood samples (over 10-fold enhancement than the surface with individual antibodies at up to 82% capture efficiency, Figure 4).
Being verbally informed of the identity of the target stimulus enhanced detection sensitivity of the named item.
Further, PEMs exhibited an antifouling property to prevent nonspecific binding of proteins and cells that enhanced detection sensitivity.
The functionalized glass ceramics show enhanced detection sensitivity.
Here we describe the development of a macroarray diagnostic technique with enhanced detection sensitivity and only small reduction in specificity.
Consequently, CP-based biosensors have been escalating as a new generation of biosensors and bioassays with ultra-low limits of detection and enhanced detection sensitivity.
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Interestingly, a number of ratiometric fluorescence probes have exhibited significantly enhanced detection sensitivities compared to single emissive quantum dot probes and so have been widely used in the construction of fluorescent probes for the detection of environmental pollutants, such as Hg2+, hydrogen sulfide, and sulfur dioxide [20 22].
A low level of caspase-8 processing was only detectable after enhancing detection sensitivity of the western blot by doubling the protein loaded on the gel and using a high-sensitivity chemiluminescent substrate (Immobilon Western HRP substrate, Millipore), indicating that TRAIL signalling is likely to be blocked at the level of the death-inducing signalling complex (DISC; Figure 2e).
The basic principle behind labelling is the derivatization of the compound of interest or the antibody (which is used to detect the compound of interest) in order to enhance detection sensitivity and selectivity, as well as to reduce matrix effects [49].
This effectively reduces background fluorescence, thereby enhance detection sensitivity.
However, reports have shown that applying these nanoparticles in sensor design could remarkably enhance detection sensitivity.
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