Exact(6)
The combination of these two factors inevitably results in the accelerated loss of crypt cells, leading to the enhanced crypt death.
Rspo1 likely promotes protection of RIGS through a combination of reduced radiation-induced apoptosis (i.e. increased cell survival), increased crypt cell proliferation with enhanced crypt regeneration, and rapid restoration of the structure and absorptive function of the villi.
Due to the enhanced crypt fission rate of K-ras mutated crypts, a sufficient number of these clonal crypts underwent fission.
K-ras mutant crypts then clonally expand within the epithelium through enhanced crypt fission, which distributes the existing Paneth cell niche over the two new crypts.
Here, upon sporadic activation of oncogenic K-ras, we provide insights into how an unequal competition between intestinal stem cells initiates a biased drift to crypt clonality that is followed by clonal expansion through enhanced crypt fission.
For example, increased crypt diversity and enhanced crypt stem cell survival is observed in some FAP patients with truncating germline mutations that remove some but not B-catenin binding repeats [ 7].
Similar(54)
The topical staining used in chromo-endoscopy has the effect of visually enhancing mucosal crypt patterns or vascular features.
Genes associated with protein biosynthesis, cellular stress and antimicrobial responses, phosphorylation, and cell cycle (including Ki67) were enhanced in the crypt epithelial cells, while villus epithelial cells displayed increased expression of genes associated with lipid and carboxylic acid metabolism, transport, EGF-like activity, and extracellular matrix functions.
The results of this study suggest that AEtLP could induce the recovery of stool number, water content, and urine quantity while enhancing villus length, crypt layer, and muscle thickness.
Statistical analysis revealed that Sb significantly enhanced cell migration along the crypt-villus axis (migration to 45% of villus height in Sb treated animals, compared to 20% of villus height in controls) (Figure 3C).
Nrf2 deficiency enhanced dextran sulfate-induced colitis, aberrant crypt foci, and colitis-associated colorectal cancer in mice.
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