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This analysis suggests that within VELOUR, patients in the better efficacy subgroup may derive enhanced benefit from treatment with FOLFIRI-aflibercept.
This post hoc survival analysis of the VELOUR study has identified a better efficacy subgroup that may have an enhanced benefit from the addition of aflibercept to FOLFIRI.
We found an association between high TS and high DPD expression, a positive prognosis in the S-1 group only, and an enhanced benefit from S-1 treatment.
This large biomarker study showed that high TS and DPD gene expression in tumors was associated with enhanced benefit from postoperative adjuvant S-1 treatment in gastric cancer.
However, this study also demonstrated that high levels of these factors predicted an enhanced benefit from adjuvant chemotherapy in certain patient groups.
In addition, relatively low interaction P values in the ER-negative and triple-negative subgroups suggested there may be an enhanced benefit from eribulin in these groups.
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Given that vancomycin administration had consistently resulted in delayed and worse mortality compared to untreated infection, we investigated whether decreasing duration of vancomycin treatment would improve survival and, therefore, enhance benefit derived from A2AAR activation.
Enhanced Benefits.
We suggest that to enhance benefits to local populations from FLR, it is necessary to better integrate socioeconomic and political data into FLR planning and implementation, to increase the role of informational implementation, and to develop monitoring and evaluation protocols to assess direct and indirect environmental and social impacts from FLR projects.
Sales of the lowly bean, which has been a staple of the Asian diet for millennia, have been skyrocketing because preliminary research suggested that soy has many life-enhancing benefits, from preventing bone density loss to easing some symptoms of menopause.
The model of Peyton seems to add an additional advantage in very early skill acquisition [ 5, 16], serving as a springboard which enhances the benefit from subsequent repetitive practice.
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